Conditions for crystallization of 4-methylmethcathinone:
- Constant temperature 22-24 ºC
- Dry air (<40% relative humidity)
- Container volume
Simple method.
We prepare a solution of isopropanol or ethanol and water in the ratio of 30/70, 50/50, 70/30. Proportion is adjusted to the task and to the volume of the container for crystallization. The more water in solution, the longer the crystal grows and larger fraction. Average proportion of mephedrone to water is 1 g per 2-3ml of solvent. The solution is preliminarily brought to a slight boil (small bubbles). Then mephedrone is added in portions so that it has time to dissolve. After all the product has dissolved, boil for a few minutes and pour the solution into a crystallization bowl. Plastic and glass bowls are mostly used. With a layer height of 1-2 cm, a fraction the size of sugar will turn out, a layer of 3-5 cm will give a fraction of up to 5 mm.
For crystallization, you can equip air-conditioned boxes, fume hoods and vacuum cabinets, use air dryers.
After solvent evaporation, wet crystals are obtained, which are well dried under cold blowing or infrared radiation (IR lamp or IR heater).
Method with gradual cooling.
When evaporation is 50% or more, crystallization centers are formed in the solution. To accelerate the crystallization process, the mixture is gradually cooled. First placed for 8-12 hours in a refrigerator T ~ (4 ºC), then for 8-12 hours in a freezer ~ (-20 ºC), depending on conditions.
Crystallization technique on the rotary evaporator (always produces a fine fraction).
Mephedrone is dissolved in a solvent in the proportion of 1 g per 1 ml. The solution is placed in the flask of the rotary evaporator and the distillation begins. The deeper the vacuum, the lower the boiling point of the solution. Large amounts of fine crystals can be obtained quickly in this way.
In the absence of a rotary evaporator, it is possible to evaporate the solution with a hot air gun from a crystallization bowl. In this case, glass or ceramic heat-resistant glassware is used. But it is important not to overheat the product, as there is a possibility of spoiling it.
Crystallization technique with rapid cooling.
Mephedrone is dissolved in hot water in the proportion of 1 g per 1 ml and brought to a boil. After complete dissolution, 0.5 alcohol or other organic polar solvent is added. The hot solution is poured into plastic containers at ½ or 2/3 of the container volume, sealed and cooled in the freezer to -20 ºC or less.
If the street temperature is negative, you can crystallize on the street.
There is a chance that the product will not all fall out, in which case you should filter the crystals and additionally evaporate the solution.
Method of crystallization in brine.
In 100 ml H2O, dissolve 23 g NaCl. In this brine dissolve 100 g of mephedrone, the solution should be heated for better solubility. The solution is poured into a plastic container for ½ or 2/3 of the container volume and sealed hermetically. Crystals grow at minus temperatures up to ~(-18 ºC). If cooled below this temperature, the brine can freeze.
- Constant temperature 22-24 ºC
- Dry air (<40% relative humidity)
- Container volume
Simple method.
We prepare a solution of isopropanol or ethanol and water in the ratio of 30/70, 50/50, 70/30. Proportion is adjusted to the task and to the volume of the container for crystallization. The more water in solution, the longer the crystal grows and larger fraction. Average proportion of mephedrone to water is 1 g per 2-3ml of solvent. The solution is preliminarily brought to a slight boil (small bubbles). Then mephedrone is added in portions so that it has time to dissolve. After all the product has dissolved, boil for a few minutes and pour the solution into a crystallization bowl. Plastic and glass bowls are mostly used. With a layer height of 1-2 cm, a fraction the size of sugar will turn out, a layer of 3-5 cm will give a fraction of up to 5 mm.
For crystallization, you can equip air-conditioned boxes, fume hoods and vacuum cabinets, use air dryers.
After solvent evaporation, wet crystals are obtained, which are well dried under cold blowing or infrared radiation (IR lamp or IR heater).
Method with gradual cooling.
When evaporation is 50% or more, crystallization centers are formed in the solution. To accelerate the crystallization process, the mixture is gradually cooled. First placed for 8-12 hours in a refrigerator T ~ (4 ºC), then for 8-12 hours in a freezer ~ (-20 ºC), depending on conditions.
Crystallization technique on the rotary evaporator (always produces a fine fraction).
Mephedrone is dissolved in a solvent in the proportion of 1 g per 1 ml. The solution is placed in the flask of the rotary evaporator and the distillation begins. The deeper the vacuum, the lower the boiling point of the solution. Large amounts of fine crystals can be obtained quickly in this way.
In the absence of a rotary evaporator, it is possible to evaporate the solution with a hot air gun from a crystallization bowl. In this case, glass or ceramic heat-resistant glassware is used. But it is important not to overheat the product, as there is a possibility of spoiling it.
Crystallization technique with rapid cooling.
Mephedrone is dissolved in hot water in the proportion of 1 g per 1 ml and brought to a boil. After complete dissolution, 0.5 alcohol or other organic polar solvent is added. The hot solution is poured into plastic containers at ½ or 2/3 of the container volume, sealed and cooled in the freezer to -20 ºC or less.
If the street temperature is negative, you can crystallize on the street.
There is a chance that the product will not all fall out, in which case you should filter the crystals and additionally evaporate the solution.
Method of crystallization in brine.
In 100 ml H2O, dissolve 23 g NaCl. In this brine dissolve 100 g of mephedrone, the solution should be heated for better solubility. The solution is poured into a plastic container for ½ or 2/3 of the container volume and sealed hermetically. Crystals grow at minus temperatures up to ~(-18 ºC). If cooled below this temperature, the brine can freeze.
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