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G.Patton

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Introduction

This topic is second part of 2C-phenylethylamines series such as 2C-E, 2C-D, 2C-B, 2C-I, 2C-F, 2C-P, 2C-T-2 and 2C-T-7 where dosages, effects, duration time, pharmacodynamics and etc were described.

2C-E

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General


2,5-Dimethoxy-4-ethylphenethylamine (also known as 2C-E, or colloquially as "Aquarust" and "Eternity") is a lesser-known psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood.

2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It began to appear in drug seizures around 2004. While primarily distributed online as a research chemical, it is also sometimes distributed on the street as 'mescaline' or 'synthetic mescaline'.



Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria. User reports characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic that is capable of producing strong visual distortions along with a significant "body load", which includes nausea and bodily discomfort.



Pharmacodynamics and neurochemistry

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens. It is highly advised to use harm reduction practices if using this substance. 2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Effects

  • Stimulation - 2C-E is usually considered to be very energetic and stimulating in a fashion that is comparable to that of MDMA, although it is 'encouraged' instead of 'forced'.
  • Spontaneous bodily sensations - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin, but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges shifting the position of one's body and prolonged tensing of unusual combinations of muscle groups.
  • Physical euphoria - Feelings of frequent, but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
  • Tactile enhancement
  • Bodily control enhancement
  • Temperature regulation suppression
  • Muscle contractions
  • Increased heart rate
  • Increased blood pressure
  • Increased perspiration
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Dehydration
  • Frequent urination
  • Pupil dilation
  • Teeth grinding - This component can be considered to be less intense when compared with that of entactogenic stimulants like MDMA.
  • Seizure - This is a rarely observed effect but is believed to be a risk in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.
Enhancements

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
Distortions

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
  • After images
  • Colour shifting
  • Scenery slicing
  • Symmetrical texture repetition
  • Tracers
Geometry

  • The visual geometry that is produced by this substance can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners.
  • Hallucinatory states
  • 2C-E produces a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This particularly holds true in comparison to other substances within the family of psychedelic phenethylamines. These effects include:
  • Transformations
  • Machinescapes
  • Internal hallucination (settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-E is extremely reliable at producing hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, and concepts. They are more likely to present themselves within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
The headspace of 2C-E is described by many as one which is both insightful and relatively unaltered in its thought processes, even at moderate to high dosages. Some users suggest that 2C-E may be even more clearheaded than 2C-B or 2C-C, especially at higher dosages.

  • Analysis enhancement - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.
  • Empathy, affection, and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.
  • Conceptual thinking
  • Creativity enhancement
  • Emotion enhancement
  • Immersion enhancement
  • Increased music appreciation
  • Memory suppression
  • Ego death
  • Novelty enhancement
  • Personal bias suppression
  • Increased libido
  • Thought acceleration
  • Thought connectivity
  • Time distortion
  • Wakefulness
  • Spirituality enhancement
  • Existential self-realization
  • Unity and interconnectedness
Trip duration: 8 - 12 h.



Dosage and methods of use: 10 - 25 mg.



The combination of which should be avoided:

Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous or even life-threatening when combined with certain other substances. The following lists some known dangerous interactions (although it is not guaranteed to include all of them).



Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume.

  • Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-E. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
  • Tramadol - Tramadol is well-documented to lower the seizure threshold, and psychedelics may act to trigger seizures in susceptible individuals.
Possible to combinations:

  • Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-E can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
  • Dissociatives - When used with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-E have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-E are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea and physical fatigue, which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, typically considered to be safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically distressing manner.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an 2C-E trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
  • Psychedelics - When used with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between these substances is unpredictable, and for this reason, generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.


2C-D

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General


2,5-Dimethoxy-4-methylphenethylamine (also known as 2C-M, LE-25 and more commonly as 2C-D) is a synthetic psychedelic of the phenethylamine chemical class that produces short-lived psychedelic effects when administered. Its sensory and cognitive effects profile has been described as being the most similar to that of mescaline among members of the 2C-x family, albeit with a significantly shorter duration. The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences. Initial trials by Alexander Shulgin at sub-threshold doses in humans were carried out in 1964. Many anecdotal reports suggest that it is calmer, easier to handle and more comfortable on the body than other closely related psychedelic phenethylamines. While not especially visual or physically euphoric at common doses, it is reported to be very lucid, analytical and unimpaired in its headspace - a quality it retains even as the dose is increased.

Pharmacodynamics and neurochemistry

Lower doses of 2C-D (generally 10 mg or less) have been explored for its use as a potential nootropic, albeit with mixed results. Today, 2C-D is used both recreationally and as an entheogen. It is rarely sold on the streets and almost exclusively distributed as a gray area research chemical by online vendors. 2C-D's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. The toxicity and long-term health effects of recreational 2C-D use do not seem to have been studied in any scientific context, and the exact toxic dose is unknown. This is because 2C-D is a research chemical with very little history of human usage. Anecdotal evidence from those within the community who have tried 2C-D suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance.

Effects

  • Stimulation - In terms of its effects on the physical energy levels of the user, the 2C-D experience begins with mild sedation that gives way to moderate stimulation as the experience progresses. It lacks the forceful, energetic push associated with most psychedelic phenethylamines.
  • Spontaneous physical sensations - The "body high" of 2C-D can be described as a pleasurable, all-encompassing comfort sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Bodily control enhancement - Whilst at lower doses one may find that their bodily control is enhanced, at higher dosages it seems to become suppressed.
  • Tactile enhancement
  • Temperature regulation suppression
  • Increased heart rate
  • Dehydration
  • Nausea - In comparison to other phenethylamines such as 2C-E, 2C-I or 2C-B, any nausea produced by this substance tends to be very mild and dissipates quickly even with higher dosages.
  • Pupil dilation
  • Analysis enhancement
  • Conceptual thinking
  • Emotion enhancement
  • Introspection
  • Increased music appreciation
  • Increased sense of humor
  • Memory suppression
  • Ego death
  • Novelty enhancement
  • Personal bias suppression
  • Thought acceleration
  • Thought connectivity
  • Time distortion
  • Existential self-realization
  • Unity and interconnectedness
Compared to other members of the 2C-x family, like 2C-B, the visual effects of 2C-D have been noted for being understated until heavier doses are reached. After this point, a full spectrum of hallucinatory visual phenomena begin to appear.

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
Distortions

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as low in detail, slow and smooth in motion, static in appearance and realistic in style.
  • Tracers
  • After images
  • Colour shifting
  • Colour tinting
  • Symmetrical texture repetition
  • Recursion
  • Diffraction
Geometry

The visual geometry of 2C-D be described as more similar in appearance to that of DOM or 25D-NBOMe than that of LSD, 2C-B or 2C-I. It can be comprehensively described as structured in its organization, organic in style, intricate in complexity, large in style, slow and smooth in motion, colorful in scheme, bright in color, blurred in its edges and equally rounded and angular in its corners. It gives off a natural feel at higher dosages. While the final level of 2C-D geometry has yet to be formally confirmed, it seems more likely that it would result in states of level 8B visual geometry over level 8A.



Hallucinatory states

  • Transformations
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-D is low in hallucinations embedded within visual geometry. However, when it does occur this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, and interactive in style.
  • External hallucination (settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - 2C-D is capable of external hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They can be described as external in their manifestation, lucid in believability, and fixed in style.
Trip duration: 4 - 6 h.



Dosage and methods of use: 20 - 60 mg.



The combination of which should be avoided:

  • Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-D. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
  • Tramadol - Tramadol is well-documented to lower the seizure threshold, and psychedelics may act to trigger seizures in susceptible individuals.


2C-B

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General

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism of action is not known. 2C-B was discovered in 1974 by the American chemist Alexander Shulgin, who was investigating psychedelic phenethylamines derived from mescaline. In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature. Recreational use was observed shortly afterward and it was briefly manufactured and sold commercially under such names as "Erox" and "Nexus" in "head" / "smart" shops and adult video stores before being federally scheduled in 1995.

Subjective effects include open and closed-eye visuals, time distortion, euphoria, and ego loss. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to mescaline, it is described as possessing a less serious or grandiose headspace than tryptamines like LSD or psilocybin mushrooms, placing greater emphasis on the visual and tactile domain. Smaller doses (under 15 mg) are reported to be useful as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.

While more research is needed, it is generally thought to be physiologically well-tolerated, with a safety profile similar to classical psychedelics, which are known to have low abuse potential and toxicity. However, adverse psychological reactions such as severe anxiety, paranoia, delusions, psychosis are always possible, particularly for those predisposed to mental disorders. It is highly advised to use harm reduction practices if using this substance.

Pharmacodynamics and neurochemistry

Unlike most psychedelics, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor partial agonist or even full antagonist. This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B. Research also suggests that 2C-B increases dopamine levels in the brains of rats which may contribute to its psychoactivity. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. Research suggests that 2C-B increases dopamine levels in the brains of rats, which may contribute to its psychoactivity.

2C-B has been shown to be metabolized by liver hepatocytes, resulting in deamination and demethylation that produces several products. Oxidative deamination results in the 2-(4-bromo-2,5-dimethoxyphenyl)-ethanol (BDMPE) and 4-bromo-2,5-dimethoxyphenylacetic acid (BDMPAA) metabolites. Additionally, 4-bromo-2,5-dimethoxybenzoic acid (BDMBA) can also be produced by oxidative deamination. Further metabolism of BDMPE and BDMPAA may occur by demethylation. Alternatively, the later metabolites can be generated by demethylation of 2C-B followed by oxidative deamination.

There is species differentiation in the metabolism of 2C-B. Mice hepatocytes produce 4-bromo-2,5-dimethoxy-phenol (BDMP), a previously unknown metabolite. Meanwhile, human, monkey and rabbit hepatocytes produce 2-(4-bromo-2-hydroxy-5-methoxyphenyl)-ethanol (B-2-HMPE), but dog, rat and mouse hepatocytes do not. 2C-B also reduces aggressive responses in drugged rats.

Effects

  • Stimulation - 2C-B is typically described as very energetic and stimulating in a fashion that draws comparisons to MDMA. At higher doses this effect can become more forced, encouraging users to engage in physical activities such as dancing.
  • Spontaneous bodily sensations - The "body high" of 2C-B is reported to be one of the most complex among psychedelics, exhibiting aspects of MDMA, 2C-E, and LSD. This is first characterized by an intense soft, warm glow that grows over the body and is capable of becoming highly euphoric.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Bodily control enhancement
  • Increased blood pressure
  • Increased bodily temperature
  • Increased heart rate
  • Increased perspiration
  • Dehydration
  • Pupil dilation
  • Tactile enhancement
  • Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.
Enhancements
  • Colour enhancement
  • Magnification
  • Pattern recognition enhancement
  • Visual acuity enhancement
Distortions
  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and cartoon-like in style.
  • After images
  • Colour shifting
  • Depth perception distortions
  • Recursion
  • Scenery slicing
  • Symmetrical texture repetition
  • Tracers
Geometry
  • The visual geometry of 2C-B is reported to be more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. It can be comprehensively described as unstructured in organization, algorithmic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in its edges and angular in its corners. It seems high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.
  • Hallucinatory states
Like LSD, while 2C-B is capable of producing a full range of low and high-level hallucinatory states, they are comparatively rare and inconsistent at higher levels while common at lower levels. They generally include the following effects:
  • Transformations
  • Machinescapes
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - Although 2C-B is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity. In comparison, these effects are extremely rare and inconsistent at common doses, though are usually readily producible at high doses, particularly when taken by rectal or intravenous routes. While traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-B will for most go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for some, 2C-B is simply not as deep of an experience as certain other psychedelics.
  • Peripheral information misinterpretation
The cognitive effects of 2C-B are often described as both insightful and relatively normal in their thought processes even at moderate to high dosages. They are often described as being halfway between LSD and MDMA.
  • Empathy, affection, and sociability enhancement - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA but still prove stronger and more consistent than other psychedelics of any class. This has been reported to provide long-lasting therapeutic effects.
  • Analysis enhancement - This introspection dominant effect is only manifested consistently in the context of a non-social setting in which the user is alone.
  • Conceptual thinking
  • Delusion
  • Creativity enhancement
  • Emotion enhancement
  • Immersion enhancement
  • Novelty enhancement
  • Increased libido
  • Increased sense of humor
  • Increased music appreciation
  • Laughter fits - Anecdotal reports and literature suggest that 2C-B is capable of producing sudden fits of mild to intense laughter.
  • Memory suppression
  • Ego death
  • Personal bias suppression
  • Rejuvenation
  • Thought acceleration
  • Thought connectivity
  • Time distortion
  • Wakefulness
Trip duration: 4 - 8 h.

Dosage and methods of use: 12 - 24 mg.


When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau lasts 2–4 hours, and coming down lasts 1–2 hours. Rectal administration onset varies from 5–20 minutes. Insufflated onset takes 1–10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on route of administration, dose, and other factors.
With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B is also considered one of the most painful drugs to insufflate, with users reporting intense nasal burning. The sudden intensity of the experience combined with the pain can often start the experience with a negative imprint and nausea is also increased with insufflation, compounding the issue.

The combinations of which should be avoided:

  • Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-B. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
  • Tramadol - Tramadol is well-documented to lower the seizure threshold and psychedelics may act to trigger seizures in susceptible individuals

Possible to combinations:

  • Cannabis - Cannabis majorly intensifies and extends both the sensory and cognitive effects of 2C-B. Extreme caution should be exercised with this combination as it can also elevate the anxiety, confusion and psychosis risk of cannabis.
  • Dissociatives - When combined with dissociatives, the geometry, euphoria, dissociation, and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-B have significantly more vivid visuals than dissociatives alone. It also results in more intense internal hallucinations and corresponding confusion which can develop into delusions and psychosis.
  • Nitrous - Nitrous oxide is commonly used in combination with psychedelics. The two are known to possess powerful cross-synergistic effects, including the capacity to send the user directly into an "ego death" state. The speed and intensity with which this occurs are very rapid and the euphoria that can result often leads to the urge to compulsively redose.
  • MDMA - MDMA strongly amplifies the physical, visual, and cognitive effects of 2C-B. This combination is reported to produce strong sensations of euphoric pleasure manifested through distinct body highs, headspaces and uniquely colorful visuals. The synergy between these substances is unpredictable, and it is advised to start with markedly lower doses than one would take for both substances individually. This combination may increase the neurotoxic effects of MDMA, based on its similarity to LSD, which has been found to increase MDMA neurotoxicity.
  • Alcohol - Alcohol can increase the disinhibiting and euphoric effects of 2C-B, lending to its use in recreational settings. It can be used in light doses to "take the edge off" a trip as well as dull its psychedelic effects in a manner comparable to benzodiazepines. However, this is not typically recommended due to alcohol’s ability to cause dehydration and nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. Heavy drinking is strongly discouraged as it can easily lead to blackouts and unpredictable behavior.
  • Benzodiazepines - Depending on the dose, benzodiazepines can slightly to completely reduce the intensity of the cognitive, physical, and visual effects of a 2C-B trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to their high abuse and addiction potential.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

2C-I

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General


2,5-Dimethoxy-4-iodophenethylamine (also known as 2C-I and "Smiles") is a psychedelic substance of the phenethylamine class. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. 2C-I was first synthesized and investigated for human activity by Alexander Shulgin in 1976 and later described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). Its PiHKAL entry notes it for being "very colorful and active" but without "feelings of insight, revelation, or progress toward the true meaning of the universe." It first briefly gained some popularity in the late 1990s and early 2000s, where it was sold in several smart shops as a replacement for 2C-B following its scheduling in 1995. It also has a history of being sold online as a research chemical before becoming scheduled. 2C-I is typically used recreationally for its psychedelic as well as moderate stimulating and entactogenic effects. It has been explored as a potential stimulant nootropic in the 1-8 mg dosage range. Little data exists about the pharmacological properties, metabolism, and toxicity of 2C-I, and it has a limited history of human use. 2C-I is sometimes confused for the analog 25I-NBOMe (an abbreviated form of 2C-I-NBOMe). It is highly advised to use harm reduction practices if using this substance.

Pharmacodynamics and neurochemistry

2C-I is a psychedelic phenethylamine of the 2C-x family. 2C-I is taken orally in tablet or capsule forms or snorted in its powder form. It has also been found impregnated on small squares of blotter paper for oral administration, which is a technique often seen for the distribution and abuse of LSD. 2C-I primarily causes stimulant and hallucinogenic effects, including increased visual, auditory, and tactile sensations. Moderate doses can cause full hallucinations and can also produce a euphoric high.



2C-I's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Effects

  • Stimulation - In terms of its effects on the physical energy levels of the user, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to MDMA, although it is 'encouraged' instead of 'forced'.
  • Spontaneous physical sensations - The "body high" of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in spontaneous waves. Alongside this, many users commonly report that the "body high" can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges of shifting the position of one's body and prolonged tensing of unusual combinations of muscle groups.
  • Physical euphoria - Feelings of frequent, but unpredictable rushes of warm physical euphoria are extremely common. These can move from the top of the head downwards before enveloping one's whole body.
  • Tactile enhancement
  • Bodily control enhancement
  • Stamina enhancement
  • Increased heart rate
  • Temperature regulation suppression
  • Muscle contractions
  • Muscle cramps
  • Muscle spasms
  • Appetite suppression
  • Dehydration
  • Frequent urination
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Pupil dilation
Enhancements

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
Distortions

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
  • Colour shifting
  • Environmental cubism - This effect is unique in that is it usually manifests simultaneously alongside or directly as a result of external geometry
  • Environmental patterning
  • Scenery slicing
  • Symmetrical texture repetition
  • Tracers
Geometry

  • The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD or 2C-B than that of 2C-E, psilocin, or ayahuasca, although it is much blander and less detailed. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy, both soft and sharp in their edges as well as equally rounded and angular in their corners. They seem high in algorithmic visuals such as fractals, and at higher doses are significantly more likely to result in states of level 8A visual geometry over level 8B.
Hallucinatory states

  • Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower ones.
  • Transformations
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - Although 2C-I is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher doses will for most simply go straight into level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that, for most, 2C-I is not as deep of an experience as certain other psychedelics.
  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
  • Unity and interconnectedness In contrast to some other psychedelics, this effect does not readily occur except at very high doses.
Trip duration: 6 - 10 h.



Dosage and methods of use: 14 - 22 mg.



The combination of which should be avoided:

Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged. Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-I. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose. Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis. Tramadol - Tramadol is well-documented to lower the seizure threshold, and psychedelics may act to trigger seizures in susceptible individuals.



2C-F

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General


2C-F, or 4-fluoro-2,5-dimethoxyphenethylamine, is a lesser-known psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin. In his book PIHKAL (Phenethylamines I Have Known and Loved), the minimum dosage is listed as 250 mg. 2C-F may be found as a brownish freebase oil, or as a white crystalline hydrochloride salt.

Effects

At a dose of 250 milligrams, 2C-F produces modest closed-eye visuals accompanied by lethargy.



A number of graded acute dosages were tried, and it was only with amounts exceeding 100 milligrams that there were any baseline disturbances at all. And at no dose that was tried was there any convincing indication of believable central effects.



Trip duration: unknown.



Dosage and methods of use: greater than 250 mg.

Even at 250 milligrams, the effects were slight and uncertain. There may have been some eyes-closed imagery above normal, but certainly not profound. At several hours, there was a pleasant lethargy; sleep was completely normal that night.



2C-P

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General


2,5-Dimethoxy-4-propylphenethylamine (also known as 2C-P) is a lesser-known novel psychedelic substance of the phenethylamine class. 2C-P is a relatively obscure member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. It is known as one of the most potent, dose-sensitive, and long-lasting of the series. Although the precise mechanism is not known, it is thought to produce its psychoactive effects by activating serotonin receptors in parts of the brain.



2C-P was first synthesized and tested for human activity by the American chemist Alexander Shulgin, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). The reports found in the 2C-P PiHKAL entry remark on its depth and long onset and duration of action, with the commentary section describing 16 mg as a clear overdose with "physical consequences." The commentary also notes the small window separating an adequate dose from an excessive dose, suggesting it is relatively easy to overdose on.



Subjective effects include open and closed-eye visuals, time distortion, conceptual thinking, euphoria, and ego loss. User reports tend to characterize the effects of 2C-P in terms of its unusually long duration, powerful, sometimes overwhelming visuals, and intense "body load" consisting of nausea, muscle tension, and general bodily discomfort. Some reports suggest it may be easier to experience agitation and delirium on 2C-P than other 2C's, perhaps owing to the ease in which it can be mis-dosed. As a result, it is considered to have an unfavorable safety profile among psychedelics.



Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-P. Due to its powerful effects and unusually long duration, 2C-P may be overly intense and difficult to use safely for those who are not highly experienced with hallucinogens. It is strongly advised to use harm reduction practices if using this substance. These include avoiding "eye-balling" (i.e. measuring the dose with the naked eye instead of a reliable milligram scale) and non-oral routes of administration. Volumetric liquid dosing is commonly recommended when dealing with substances of this potency.

Pharmacodynamics and neurochemistry

2C-P is a relatively potent and long acting psychedelic phenethylamine of the 2C family, which possesses stimulant type effects as well. It was first described by Alexander Shulgin in his book PiHKAL. 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, it can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours. 2C-P has been shown to produce a variety of intense hallucinogenic type effects, ranging from drastic changes in consciousness and perception, to open and closed eye visuals. 2C-P is considered to be one of the strongest 2C-x compounds dosage for dosage, rivaled only by 2C-TFM.



2C-P's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how it results in the psychedelic experience continues to remain elusive.

Effects

  • Stimulation - 2C-P is considered to be very energetic and stimulating in a fashion that is comparable to that of 2C-B, 2C-I and other substances within the 2C-x family, being encouraged instead of forced.
  • Spontaneous bodily sensations - In comparison to 2C-E or 2C-B, the "body high" of 2C-P can be considered as mild, although still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. This is coupled by an equally intense yet slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body, as well as a slight warm glow that manifests itself much less consistently than the other two physical components. All of these are capable of becoming very physically euphoric.
  • Tactile enhancement - This effect is particularly prominent, but capable of going in both pleasurable and uncomfortable directions. This can result in pleasurable tactile sensations, but also enhances bodily aches and pains which one may not have previously been aware of to the point of extreme discomfort.
  • Bodily control enhancement
  • Temperature regulation suppression - 2C-P is reported to be able to cause large perceived increases and decreases in temperature in a dose dependent manner. This can become extremely uncomfortable, if not dangerous at larger doses due to the fever-like delirium that is sometimes reported.
  • Increased bodily temperature
  • Increased heart rate
  • Increased blood pressure
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Increased libido - A common theme found in many 2C-P reports is the way in which it can heighten and enhance sexual arousal. When experienced, this sensation is not overwhelming or out of control, but simply remains something that the user is constantly aware of. If sexual activities of any kind are engaged in, they have been reported to be immensely more pleasurable than anything that can be achieved in a sober state.
  • Pupil dilation
  • Teeth grinding - A very common effect of 2C-P, and more pronounced with 2C-P than other 2C's or psychedelic substances in general. Can become very uncomfortable, especially with higher doses.
Enhancements

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
  • Distortions
  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
  • Tracers
  • After images
  • Symmetrical texture repetition
  • Color shifting
  • Scenery slicing
  • Depth perception distortions
Geometry

The visual geometry present can be described as being more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A. There seems to be visual geometry that is distinct from 2C-E, psilocin and ayahuasca and can be described as faster moving and more intense in proportion to cognitive and physical effects than 2C-E.



Hallucinatory states

  • 2C-P produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other 2C-x phenethylamines such as 2C-B or 2C-I. These effects include:
  • Machinescapes
  • Transformations
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-P is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
  • Unspeakable horrors - This is an effect that is typically associated with deliriants rather than psychedelics. Based on anecdotal reports, they only tend to occur at higher doses and are likely a result of the pronounced temperature increasing properties this substance has compared to other 2C-x and psychedelics, which can lend readily to delirium-like states.
The cognitive effects of 2C-P have been described as both insightful and relatively normal in their thought processes up to moderate dosages, after which their confusing, and disorienting effects can increase considerably.

  • Analysis enhancement
  • Conceptual thinking
  • Creativity enhancement
  • Delusion
  • Autonomous voice communication
  • Emotion enhancement
  • Immersion enhancement
  • Increased music appreciation
  • Memory suppression
  • Ego death
  • Multiple thought streams
  • Novelty enhancement
  • Personal bias suppression
  • Personal meaning enhancement
  • Thought acceleration
  • Thought loops
  • Time distortion
  • Wakefulness
Trip duration: 10 - 16 h.



Dosage and methods of use: 6 - 10 mg.



In his book PiHKAL, Shulgin listed 2C-P's dosage range as 6–10 mg and wrote that while most reports with dosages between 6 and 12 mg were favorable, "there was one report of an experience in which a single dosage of 16 mg was clearly an overdose, with the entire experiment labeled a physical disaster, not to be repeated." He cautioned readers regarding dosing with 2C-P by commenting that "a consistent observation is that there may not be too much latitude in dosage between that which would be modest, or adequate, and that which would be excessive. The need for individual titration would be most important with this compound." 2C-P is one of the most potent compounds in the 2C family of psychedelics, rivaled only by 2C-TFM.



The combination of which should be avoided:

  • Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 2C-P. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
  • Tramadol - Tramadol is well-documented to lower the seizure threshold, and psychedelics may act to trigger seizures in susceptible individuals.


2C-T-2

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General


2,5-Dimethoxy-4-ethylthiophenethylamine (also known as 2C-T-2, and Rosy) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.



2C-T-2 was first synthesized and tested for activity in humans by Alexander Shulgin in 1981 and described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. Anecdotal reports generally characterize 2C-T-2 as a highly dose sensitive psychedelic known for its open headspace and unpredictable body load.



Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has a relatively short history of human usage. Many reports also indicate that its physical effects may be too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions. It is highly advised to approach this hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.

Pharmacodynamics and neurochemistry

The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.



Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 positions (4-MTA, and the 2,5-desmethoxy derivative of 2C-T-7) are known to act as selective monoamine oxidase A inhibitors. Furthermore, many compounds of the amphetamine-analogs of the 2C-T-x have been found to have highly selective MAO-A inhibition. Therefore, this substance may likewise have MAOI effects. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Effects

  • Stimulation - 2C-T-2 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P.
  • Spontaneous physical sensations - The "body high" of 2C-T-2 can be described as very intense and uncomfortable in comparison to 2C-E or 2C-B. In high doses, it's capable of causing painful cramping. It is similar yet distinct from the "body high" experienced on 2C-T-7, but is considered much more unpleasant. The sensation itself can be described as intense and may manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users, it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
  • Tactile enhancement
  • Nausea - Extreme nausea is commonly reported when consumed in moderate to high doses and either passes once the tripper has vomited or gradually fades by itself as the peak sets in. It can be described as very painful and violent in comparison to 2C-T-7 or 2C-E.
  • Stomach cramps
  • Vasoconstriction
  • Diarrhea
  • Temperature regulation suppression
  • Increased bodily temperature
  • Increased heart rate
  • Pupil dilation
Enhancements

  • Visual acuity enhancement
  • Colour enhancement
  • Pattern recognition enhancement
Distortions

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and extremely realistic in style but with a subtle digital/cartoon-like form.
  • Tracers
  • After images
  • Symmetrical texture repetition
  • Colour shifting
  • Scenery slicing
Geometry

The visual geometry that is present throughout this experience can be described as somewhat similar in appearance to that of ayahuasca, psilocin, and 4-AcO-DMT with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of LSD or 2C-E. 2C-T-2's geometry can be comprehensively described through its variations as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them, which is reminiscent of DOC or 2C-P. Higher doses are more likely to result in states of level 8B visual geometry, but may also lead into level 8A visual geometry (as with 2C-T-7).



Hallucinatory states

At common to high doses, 2C-T-2 is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamines family. These effects include:

  • Transformations
  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as ayahuasca, 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-T-2 is very high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.


The headspace of 2C-T-2 is described by many as one which is both insightful and relatively normal in its thought processes, even at moderate to high doses.

  • Emotion enhancement
  • Novelty enhancement
  • Time distortion
  • Analysis enhancement - This effect is consistent in its manifestation and is outrospection dominant.
  • Personal bias suppression
  • Conceptual thinking
  • Increased music appreciation
  • Increased sense of humor
  • Immersion enhancement
  • Memory suppression
  • Ego death
  • Thought acceleration
  • Thought loops
  • Delusion
  • Wakefulness
Transpersonal effects

  • Existential self-realization
  • Perception of interdependent opposites
  • Unity and interconnectedness
Trip duration: 6 — 8 h.



Dosage and methods of use: 12 - 25 mg.



The combination of which should be avoided:

If 2C-T-2 does have MAOI effects as has been speculated, this could indicate that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics. This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include, but are not limited to:

  • 5-MeO-MiPT
  • 2C-T-7
  • AMT
  • Ayahuasca
  • Harmala alkaloids
  • 2-AI
  • 2-FMA
  • 3-FPM
  • 4-FA
  • A-PVP
  • Amphetamine
  • Cocaine
  • Ethylphenidate
  • N-Methylbisfluoromodafinil
  • Isopropylphenidate
  • MDAI
  • MDMA
  • Mephedrone
  • Methamphetamine
  • Methiopropamine
  • Methylone
  • Methylphenidate
  • Modafinil
  • Nicotine
  • NM-2-AI
  • Noopept


2C-T-7

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General


2,5-Dimethoxy-4-propylthiophenethylamine (also known as 2C-T-7, Blue Mystic, and Beautiful, among others) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic and entactogenic effects when administered. 2C-T-7 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. In contrast to other members of the 2C-x family, 2C-T-7 has gained a reputation of being an unpredictable, dose-sensitive psychedelic capable of producing strong visual effects and an intense body load, which can manifest as a dangerous delirium in extreme cases. Many reports indicate that the physical effects are too severe for inexperienced users or those with pre-existing medical conditions.



This particular compound is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which -- except for mescaline -- he designed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.

Pharmacodynamics and neurochemistry

2C-T-7's psychedelic effects have been shown to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.



With serious adverse effects seen on overdoses of this compound (potentially Serotonin Syndrome) and as the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor and many of the amphetamine-analogs of the 2C-T-x series are highly selective MAO-A inhibitors (with ALEPH-7 being one of the most potent), this substance is widely thought to also have MAOI effects.



Effects

  • Stimulation - In terms of its effects on the physical energy levels of the user, 2C-T-7 is generally considered to be energetic and stimulating in a fashion is comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P. However, at certain doses and contexts, it may produce periods of notable sedation.
  • Spontaneous physical sensations - The "body high" of 2C-T-7 is intense, but in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion, for most users it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
  • Changes in felt bodily form
  • Tactile enhancement
  • Temperature regulation suppression
  • Increased bodily temperature
  • Abnormal heartbeat
  • Increased blood pressure
  • Increased heart rate
  • Dehydration
  • Diarrhea
  • Difficulty urinating or Frequent urination
  • Dizziness
  • Headaches
  • Increased perspiration
  • Muscle contractions
  • Muscle spasms
  • Muscle cramps
  • Nausea - Mild to extreme nausea is commonly reported when consumed in moderate to high dosages, and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Stomach bloating
  • Stomach cramps
  • Teeth grinding
  • Excessive yawning
  • Pupil dilation
  • Watery eyes
Enhancements

  • Visual acuity enhancement
  • Colour enhancement
  • Pattern recognition enhancement
Distortions

  • Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and extremely realistic in style but with a subtle digital/cartoonish form.
  • Tracers
  • After images
  • Symmetrical texture repetition
  • Colour shifting
  • Scenery slicing
Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel, with slightly more mystical and shamanic undertones in comparison to other phenethylamines. At higher dosages, they are equally likely to result in states of Level 8A visual geometry or Level 8B. There seems to be a visual geometry that is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity and equal in proportion to the accompanying cognitive and physical effects.



Hallucinatory states

2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

  • Transformations
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
The headspace of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes, even at moderate to high dosages.

  • Emotion enhancement
  • Thought acceleration
  • Novelty enhancement
  • Time distortion
  • Increased music appreciation
  • Analysis enhancement
  • Personal bias suppression
  • Conceptual thinking
  • Memory suppression
  • Ego death
  • Immersion enhancement
  • Thought loops
  • Delusion
  • Wakefulness
Auditory effects

  • Enhancements
  • Distortions
  • Hallucinations
Trip duration: 8 - 15 h.



Dosage and methods of use: 10 - 30 mg.



The combination of which should be avoided:

If 2C-T-7 does have MAOI effects as commonly speculated, this could indicate that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics. This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include, but are not limited to:

  • 5-MeO-MiPT
  • 2C-T-2
  • AMT
  • Ayahuasca
  • Harmala alkaloids
  • 2-AI
  • 2-FMA
  • 3-FPM
  • 4-FA
  • A-PVP
  • Amphetamine
  • Cocaine
  • Ethylphenidate
  • N-Methylbisfluoromodafinil
  • Isopropylphenidate
  • MDAI
  • MDMA
  • Mephedrone
  • Methamphetamine
  • Methiopropamine
  • Methylone
  • Methylphenidate
  • Modafinil
  • Nicotine
  • NM-2-AI
  • Noopept
 
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